Two hormones, estrogen and progesterone, are crucial for a woman’s reproductive system. Estrogen regulates the menstrual cycle and prepares the uterus for pregnancy, while progesterone thickens the uterus lining for fertilized eggs and breast milk production. These hormones also regulate mood, bone health, and brain function. Prolonged exposure to estrogen and progesterone increases a woman’s risk of developing breast cancer, as they stimulate the growth of hormone-sensitive or hormone-dependent breast cancer cells.
“Hormone-sensitive breast cancer cells contain hormone receptors—estrogen receptors or ERs, and progesterone receptors or PRs. These receptors are proteins that activate when hormones bind to them,” explains Melodie Grace M. Remorca, MD, from the Breast Imaging Center of the top hospital in the Philippines, Makati Medical Center (MakatiMed). “Once activated, these receptors affect specific genes, which, in turn, stimulate cell growth.”
Once thought to be caused by genetics (actress Angelina Jolie famously underwent a preventive double mastectomy in 2013 after learning she had the mutated BRCA1 gene, which puts her at risk of developing breast and ovarian cancer) or unhealthy lifestyle practices, the disease can be triggered by hormones, too. About 2 out of 3 breast cancers are hormone receptor-positive, says the American Cancer Society.
Hormone-sensitive breast cancer is treated with hormone therapy, which works by reducing the production of estrogen and progesterone in the body or by preventing hormones from binding to the receptors on cancer cells.
“Depending on the type of hormone therapy, this protocol can also slow the growth of cancer that has spread, and lower the risk of cancer developing in other breast tissue,” the doctor says. Used in combination with surgery, chemotherapy, and radiation therapy, hormone therapy can be given before surgery to shrink the tumor, making it easier for doctors to remove. When given after surgery, a patient takes it for at least five years.
If you note any symptoms of breast cancer (a lump in your breast, nipple inversion or discharge, changes in the size or shape of your breast), see a specialist immediately for an initial screening.
Hailed as the pioneer in breast imaging in the Philippines, the Breast Imaging Center at MakatiMed has offered cutting-edge and cost-effective breast cancer imaging services since 1993—from the digital breast tomosynthesis (3D mammography) to breast ultrasound (sonomammogram).
Run by an all-women team of breast radiologists, specialized radiologic technologists, specialty-trained nurses, and admin staff, the clinic also conducts ultrasound-guided core needle biopsy, stereotactic core needle biopsy, wire needle localization, cyst aspiration, fine needle aspiration biopsy, biopsy clip placement, and galactography (a medical imaging procedure used to visualize the milk ducts of the breast).
High-tech imaging and interventional procedures can determine whether you have breast cancer and the appropriate steps to address it.
“Hormone therapy is regarded as an effective approach to treating hormone-sensitive breast cancer. It has also been shown to reduce the incidence of recurrence and improve survival rates,” shares Dr. Remorca. “Of course, the type and stage of the cancer and a patient’s overall health ultimately play a role in a patient’s prognosis, so early detection is still crucial to a favorable outcome.”
For more information, please get in touch with MakatiMed On-Call at +632.88888 999, email [email protected], or visit www.makatimed.net.ph. Follow @IamMakatiMed on Facebook and Twitter.
